Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing
نویسندگان
چکیده
منابع مشابه
Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing.
Glucose homeostasis is controlled by insulin in part through the translocation of intracellular glucose transporter 4 to the plasma membrane in muscle and fat cells. Akt/protein kinase B downstream of phosphatidylinositol 3-kinase has been implicated in this insulin-signaling pathway, but results with a variety of reagents including Akt1-/- and Akt2-/- mice have been equivocal. Here we report t...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2003
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1332633100